President Barack Obama delivered a live address to the nation on the tragedy:
This is an especially heartbreaking day for all our friends -- our fellow Americans -- who are lesbian, gay, bisexual or transgender. The shooter targeted a nightclub where people came together to be with friends, to dance and to sing, and to live. The place where they were attacked is more than a nightclub -- it is a place of solidarity and empowerment where people have come together to raise awareness, to speak their minds, and to advocate for their civil rights. So this is a sobering reminder that attacks on any American -- regardless of race, ethnicity, religion or sexual orientation -- is an attack on all of us and on the fundamental values of equality and dignity that define us as a country. And no act of hate or terror will ever change who we are or the values that make us Americans. Today marks the most deadly shooting in American history. The shooter was apparently armed with a handgun and a powerful assault rifle. This massacre is therefore a further reminder of how easy it is for someone to get their hands on a weapon that lets them shoot people in a school, or in a house of worship, or a movie theater, or in a nightclub. And we have to decide if that’s the kind of country we want to be. And to actively do nothing is a decision as well.A very sad day indeed!